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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
22.42
Human Site:
S39
Identified Species:
30.83
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
S39
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
S77
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
S39
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
Dog
Lupus familis
XP_538078
377
41675
S39
A
K
V
P
K
R
A
S
M
V
H
S
L
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
S39
V
K
V
P
K
R
A
S
M
V
H
S
L
I
E
Rat
Rattus norvegicus
Q4QQW4
482
55074
M37
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
S333
S
K
V
P
K
R
A
S
M
V
H
S
L
I
E
Chicken
Gallus gallus
P56517
480
54920
M37
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Frog
Xenopus laevis
O42227
480
54874
M37
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
L37
S
L
T
H
S
L
V
L
H
Y
G
L
Y
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
H37
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
G
Honey Bee
Apis mellifera
XP_394976
461
52425
E53
P
H
K
A
T
A
D
E
M
T
K
F
H
S
D
Nematode Worm
Caenorhab. elegans
O17695
461
52119
R40
V
M
K
P
H
R
I
R
M
T
H
H
L
V
L
Sea Urchin
Strong. purpuratus
P56518
576
64060
H38
P
H
R
I
R
M
T
H
N
L
I
L
N
Y
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
R50
P
M
K
P
H
R
I
R
M
T
H
S
L
L
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
I38
L
C
M
T
H
H
L
I
L
A
Y
G
L
H
S
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
R46
P
M
K
P
H
R
I
R
M
A
H
S
L
I
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
100
93.3
N.A.
86.6
13.3
N.A.
86.6
13.3
13.3
0
N.A.
0
6.6
33.3
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
33.3
N.A.
100
33.3
33.3
13.3
N.A.
13.3
13.3
40
13.3
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
40
N.A.
6.6
46.6
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
0
6
0
6
36
0
0
12
0
0
0
0
6
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
6
% D
% Glu:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
36
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
6
6
0
0
12
% G
% His:
0
18
0
24
24
6
0
12
6
18
53
6
6
6
0
% H
% Ile:
0
0
18
12
0
18
18
6
0
0
6
0
0
42
0
% I
% Lys:
0
53
24
0
36
0
0
0
0
0
6
0
0
6
6
% K
% Leu:
6
6
0
0
0
6
6
6
6
12
6
36
77
24
6
% L
% Met:
18
18
6
0
0
12
0
18
59
0
0
0
0
0
6
% M
% Asn:
0
0
0
0
0
0
0
0
12
0
18
0
12
0
18
% N
% Pro:
30
0
18
53
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
12
0
30
53
18
18
0
0
0
0
0
0
0
% R
% Ser:
12
0
0
0
6
0
0
36
0
0
0
48
0
6
6
% S
% Thr:
0
0
6
6
6
0
12
0
18
18
0
0
0
0
0
% T
% Val:
12
0
18
0
0
0
6
0
0
36
0
0
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
6
6
0
6
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _